ICD-10-CM C49: Malignant neoplasm of other connective and soft tissue

ICD-10-CM Diagnosis Code (2025)

Official Description for C49

Malignant neoplasm of other connective and soft tissue

Coding Notes & Guidelines for C49

Includes Notes
  • malignant neoplasm of blood vessel
  • malignant neoplasm of bursa
  • malignant neoplasm of cartilage
  • malignant neoplasm of fascia
  • malignant neoplasm of fat
  • malignant neoplasm of ligament, except uterine
  • malignant neoplasm of lymphatic vessel
  • malignant neoplasm of muscle
  • malignant neoplasm of synovia
  • malignant neoplasm of tendon (sheath)
Excludes1: Not Coded Here
  • malignant neoplasm of cartilage (of):
  • articular (C40-C41)
  • larynx (C32.3)
  • nose (C30.0)
  • malignant neoplasm of connective tissue of breast (C50.-)
Excludes1: Not Coded Here

connective tissue of orbit (C69.6-)

Excludes1: Not Coded Here
  • malignant neoplasm of breast (C50.-)
  • malignant neoplasm of heart (C38.0)
  • malignant neoplasm of mediastinum (C38.1-C38.3)
  • malignant neoplasm of thymus (C37)
Excludes2: Not Included Here
  • Kaposi's sarcoma of soft tissue (C46.1)
  • malignant neoplasm of heart (C38.0)
  • malignant neoplasm of peripheral nerves and autonomic nervous system (C47.-)
  • malignant neoplasm of peritoneum (C48.2)
  • malignant neoplasm of retroperitoneum (C48.0)
  • malignant neoplasm of uterine ligament (C57.3)
  • mesothelioma (C45.-)
Inclusion Terms
  • Malignant neoplasm of connective tissue of ear
  • Malignant neoplasm of connective tissue of eyelid
Inclusion Terms
  • Malignant neoplasm of axilla
  • Malignant neoplasm of diaphragm
  • Malignant neoplasm of great vessels
Inclusion Terms
  • Malignant neoplasm of abdominal wall
  • Malignant neoplasm of hypochondrium
Inclusion Terms
  • Malignant neoplasm of buttock
  • Malignant neoplasm of groin
  • Malignant neoplasm of perineum
Inclusion Terms

Malignant neoplasm of back NOS

Inclusion Terms

Primary malignant neoplasm of two or more contiguous sites of connective and soft tissue

Child Codes (More Specific Codes for C49):

C49.0 - Malignant neoplasm of connective and soft tissue of head, face and neck C49.1 - Malignant neoplasm of connective and soft tissue of upper limb, including shoulder C49.10 - Malignant neoplasm of connective and soft tissue of unspecified upper limb, including shoulder C49.11 - Malignant neoplasm of connective and soft tissue of right upper limb, including shoulder C49.12 - Malignant neoplasm of connective and soft tissue of left upper limb, including shoulder C49.2 - Malignant neoplasm of connective and soft tissue of lower limb, including hip C49.20 - Malignant neoplasm of connective and soft tissue of unspecified lower limb, including hip C49.21 - Malignant neoplasm of connective and soft tissue of right lower limb, including hip C49.22 - Malignant neoplasm of connective and soft tissue of left lower limb, including hip C49.3 - Malignant neoplasm of connective and soft tissue of thorax C49.4 - Malignant neoplasm of connective and soft tissue of abdomen C49.5 - Malignant neoplasm of connective and soft tissue of pelvis C49.6 - Malignant neoplasm of connective and soft tissue of trunk, unspecified C49.8 - Malignant neoplasm of overlapping sites of connective and soft tissue C49.9 - Malignant neoplasm of connective and soft tissue, unspecified C49.A - Gastrointestinal stromal tumor C49.A0 - Gastrointestinal stromal tumor, unspecified site C49.A1 - Gastrointestinal stromal tumor of esophagus C49.A2 - Gastrointestinal stromal tumor of stomach C49.A3 - Gastrointestinal stromal tumor of small intestine C49.A4 - Gastrointestinal stromal tumor of large intestine C49.A5 - Gastrointestinal stromal tumor of rectum C49.A9 - Gastrointestinal stromal tumor of other sites

About ICD-10-CM Code C49 (Malignant neoplasm of other connective and soft tissue)

ICD-10-CM code C49 is a billable or specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes. The 2025 edition of ICD-10-CM C49 became effective on October 1, 2024.

This page provides detailed information about C49 - Malignant neoplasm of other connective and soft tissue. It includes common terminology, coding guidelines such as "Includes," "Excludes1," and "Excludes2" notes, and information on required 7th characters. Utilizing this information correctly is essential for accurate medical coding and claims submission for conditions like Malignant neoplasm of other connective and soft tissue.