ICD-10-CM C88: Malignant immunoproliferative diseases and certain other B-cell lymphomas

ICD-10-CM Diagnosis Code (2025)

Official Description for C88

Malignant immunoproliferative diseases and certain other B-cell lymphomas

Coding Notes & Guidelines for C88

Excludes1: Not Coded Here
  • B-cell lymphoma, unspecified (C85.1-)
  • personal history of other malignant neoplasms of lymphoid, hematopoietic and related tissues (Z85.79)
Excludes1: Not Coded Here

small cell B-cell lymphoma (C83.0)

Excludes1: Not Coded Here

high malignant (diffuse large B-cell) lymphoma (C83.3-)

Inclusion Terms
  • Lymphoplasmacytic lymphoma with IgM-production
  • Macroglobulinemia (idiopathic) (primary)
Inclusion Terms
  • Lymphoplasmacytic lymphoma with IgM-production, NOS
  • Lymphoplasmacytic lymphoma with IgM-production not having achieved remission
  • Lymphoplasmacytic lymphoma with IgM-production with failed remission
  • Macroglobulinemia (idiopathic) (primary) NOS
  • Macroglobulinemia (idiopathic) (primary) not having achieved remission
  • Macroglobulinemia (idiopathic) (primary) with failed remission
  • Waldenström macroglobulinemia NOS
  • Waldenström macroglobulinemia with failed remission
Inclusion Terms
  • Franklin disease
  • Gamma heavy chain disease
  • Mu heavy chain disease
Inclusion Terms
  • Franklin disease NOS
  • Franklin disease not having achieved remission
  • Franklin disease with failed remission
  • Gamma heavy chain disease NOS
  • Gamma heavy chain disease not having achieved remission
  • Gamma heavy chain disease with failed remission
  • Heavy chain disease NOS
  • Heavy chain disease with failed remissionMu heavy chain disease not having achieved remission
  • Mu heavy chain disease NOS
  • Mu heavy chain disease not having achieved remission
  • Mu heavy chain disease with failed remission
Inclusion Terms
  • Alpha heavy chain disease
  • Mediterranean lymphoma
Inclusion Terms
  • Alpha heavy chain disease NOS
  • Alpha heavy chain disease not having achieved remission
  • Alpha heavy chain disease with failed remission
  • Immunoproliferative small intestinal disease NOS
  • Immunoproliferative small intestinal disease with failed remission
  • Mediterranean lymphoma NOS
  • Mediterranean lymphoma not having achieved remission
  • Mediterranean lymphoma with failed remission
Inclusion Terms
  • Lymphoma of skin-associated lymphoid tissue [SALT-lymphoma]
  • Lymphoma of bronchial-associated lymphoid tissue [BALT-lymphoma]
Inclusion Terms
  • Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue [MALT-lymphoma] NOS
  • Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue [MALT-lymphoma] with failed remission
  • Lymphoma of bronchial-associated lymphoid tissue [BALT-lymphoma] NOS
  • Lymphoma of bronchial-associated lymphoid tissue [BALT-lymphoma] not having achieved remission
  • Lymphoma of bronchial-associated lymphoid tissue [BALT-lymphoma] with failed remission
  • Lymphoma of skin-associated lymphoid tissue [SALT-lymphoma] NOS
  • Lymphoma of skin-associated lymphoid tissue [SALT-lymphoma] not having achieved remission
  • Lymphoma of skin-associated lymphoid tissue [SALT-lymphoma] with failed remission
Inclusion Terms
  • Other malignant immunoproliferative diseases NOS
  • Other malignant immunoproliferative diseases with failed remission
Inclusion Terms

Immunoproliferative disease NOS

Inclusion Terms
  • Immunoproliferative disease NOS
  • Immunoproliferative disease NOS not having achieved remission
  • Immunoproliferative disease NOS with failed remission
  • Malignant immunoproliferative disease, unspecified NOS
  • Malignant immunoproliferative disease, unspecified with failed remission

Child Codes (More Specific Codes for C88):

C88.0 - Waldenström macroglobulinemia C88.00 - Waldenström macroglobulinemia not having achieved remission C88.01 - Waldenström macroglobulinemia, in remission C88.2 - Heavy chain disease C88.20 - Heavy chain disease not having achieved remission C88.21 - Heavy chain disease, in remission C88.3 - Immunoproliferative small intestinal disease C88.30 - Immunoproliferative small intestinal disease not having achieved remission C88.31 - Immunoproliferative small intestinal disease, in remission C88.4 - Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue [MALT-lymphoma] C88.40 - Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue [MALT-lymphoma] not having achieved remission C88.41 - Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue [MALT-lymphoma], in remission C88.8 - Other malignant immunoproliferative diseases C88.80 - Other malignant immunoproliferative diseases not having achieved remission C88.81 - Other malignant immunoproliferative diseases, in remission C88.9 - Malignant immunoproliferative disease, unspecified C88.90 - Malignant immunoproliferative disease, unspecified not having achieved remission C88.91 - Malignant immunoproliferative disease, unspecified, in remission

About ICD-10-CM Code C88 (Malignant immunoproliferative diseases and certain other B-cell lymphomas)

ICD-10-CM code C88 is a billable or specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes. The 2025 edition of ICD-10-CM C88 became effective on October 1, 2024.

This page provides detailed information about C88 - Malignant immunoproliferative diseases and certain other B-cell lymphomas. It includes common terminology, coding guidelines such as "Includes," "Excludes1," and "Excludes2" notes, and information on required 7th characters. Utilizing this information correctly is essential for accurate medical coding and claims submission for conditions like Malignant immunoproliferative diseases and certain other B-cell lymphomas.