ICD-10-CM D57.4: Sickle-cell thalassemia

ICD-10-CM Diagnosis Code (2025)

Official Description for D57.4

Sickle-cell thalassemia

Coding Notes & Guidelines for D57.4

Use Additional Code
  • code to identify complications, such as:
  • cholelithiasis (K80.-)
  • priapism (N48.32)
Use Additional Code
  • code to identify complications, such as:
  • cholelithiasis (K80.-)
  • priapism (N48.32)
Use Additional Code
  • code to identify complications, such as:
  • cholelithiasis (K80.-)
  • priapism (N48.32)
Inclusion Terms
  • Sickle-cell beta thalassemia
  • Thalassemia Hb-S disease
Inclusion Terms
  • Microdrepanocytosis
  • Sickle-cell thalassemia NOS
Inclusion Terms
  • Sickle-cell thalassemia with (painful) crisis NOS
  • Sickle-cell thalassemia with (vaso-occlusive) pain NOS
Inclusion Terms
  • Sickle-cell thalassemia with (painful) crisis NOS
  • Sickle-cell thalassemia with (vaso-occlusive) pain NOS
Inclusion Terms
  • HbS-beta zero without crisis
  • Sickle-cell beta zero without crisis
Inclusion Terms
  • HbS-beta zero with crisis
  • Sickle-cell beta zero with crisis
Inclusion Terms
  • HbS-beta zero with acute chest syndrome
  • Sickle-cell beta zero with acute chest syndrome
Inclusion Terms
  • HbS-beta zero with splenic sequestration
  • Sickle-cell beta zero with splenic sequestration
Inclusion Terms
  • HbS-beta zero with cerebral vascular involvement
  • Sickle-cell beta zero with cerebral vascular involvement
Inclusion Terms
  • HbS-beta zero with other specified complication
  • Sickle-cell beta zero with other specified complication
Inclusion Terms
  • HbS-beta zero with other specified complication
  • Sickle-cell beta zero with crisis unspecified
  • Sickle-cell thalassemia beta zero with (painful) crisis NOS
  • Sickle-cell thalassemia beta zero with (vaso-occlusive) pain NOS
Inclusion Terms
  • HbS-beta plus without crisis
  • Sickle-cell beta plus without crisis
Inclusion Terms
  • HbS-beta plus with crisis
  • Sickle-cell beta plus with crisis
Inclusion Terms
  • HbS-beta plus with acute chest syndrome
  • Sickle-cell beta plus with acute chest syndrome
Inclusion Terms
  • HbS-beta plus with splenic sequestration
  • Sickle-cell beta plus with splenic sequestration
Inclusion Terms
  • HbS-beta plus with cerebral vascular involvement
  • Sickle-cell beta plus with cerebral vascular involvement
Inclusion Terms
  • HbS-beta plus with crisis with other specified complication
  • Sickle-cell beta plus with crisis with other specified complication
Inclusion Terms
  • HbS-beta plus with crisis with unspecified complication
  • Sickle-cell beta plus with crisis with unspecified complication
  • Sickle-cell thalassemia beta plus with (painful) crisis NOS
  • Sickle-cell thalassemia beta plus with (vaso-occlusive) pain NOS
Code Also

, if applicable cerebral infarction (I63.-)

Code Also

, if applicable cerebral infarction (I63.-)

Code Also

, if applicable cerebral infarction (I63.-)

Parent Code (Less Specific):

D57 - Sickle-cell disorders

About ICD-10-CM Code D57.4 (Sickle-cell thalassemia)

ICD-10-CM code D57.4 is a billable or specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes. The 2025 edition of ICD-10-CM D57.4 became effective on October 1, 2024.

This page provides detailed information about D57.4 - Sickle-cell thalassemia. It includes common terminology, coding guidelines such as "Includes," "Excludes1," and "Excludes2" notes, and information on required 7th characters. Utilizing this information correctly is essential for accurate medical coding and claims submission for conditions like Sickle-cell thalassemia.