ICD-10-CM D59: Acquired hemolytic anemia

ICD-10-CM Diagnosis Code (2025)

Official Description for D59

Acquired hemolytic anemia

Coding Notes & Guidelines for D59

Excludes1: Not Coded Here

hemoglobinuria NOS (R82.3)

Excludes1: Not Coded Here

hemoglobinuria NOS (R82.3)

Excludes2: Not Included Here
  • Evans syndrome (D69.41)
  • hemolytic disease of newborn (P55.-)
  • paroxysmal cold hemoglobinuria (D59.6)
Code First
  • , if applicable, any associated:
  • COVID-19 (U07.1)
  • complications of kidney transplant (T86.1-)
  • complications of heart transplant (T86.2-)
  • complications of liver transplant (T86.4-)
Use Additional Code

code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)

Use Additional Code

code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)

Use Additional Code
  • code to identify associated infection, such as :
  • E. coli infection (B96.2-)
  • Human immunodeficiency virus [HIV] disease (B20)
  • Pneumococcal meningitis (G00.1)
  • Pneumococcal pneumonia (J13)
  • Sepsis due to Streptococcus pneumoniae (A40.3)
  • Shigella dysenteriae (A03.9)
  • Streptococcus pneumoniae as the cause of diseases classified elsewhere (B95.3)
Use Additional Code

code, if applicable, for adverse effect to identify drug (T36-T50 with fifth or sixth character 5)

Use Additional Code

code (Chapter 20) to identify external cause

Inclusion Terms
  • Warm type (primary) (secondary) (symptomatic) autoimmune hemolytic anemia
  • Warm type autoimmune hemolytic disease
Inclusion Terms
  • Chronic cold hemagglutinin disease
  • Cold agglutinin disease
  • Cold agglutinin hemoglobinuria
  • Cold type (primary) (secondary) (symptomatic) autoimmune hemolytic anemia
  • Cold type autoimmune hemolytic disease
Inclusion Terms
  • Mixed type autoimmune hemolytic disease
  • Mixed type, cold and warm, (primary) (secondary) (symptomatic) autoimmune hemolytic anemia
Inclusion Terms

Drug-induced enzyme deficiency anemia

Inclusion Terms

Hemolytic-uremic syndrome NOS

Inclusion Terms
  • Shiga toxin-producing E. coli [STEC] related hemolytic uremic syndrome
  • Typical hemolytic uremic syndrome
Inclusion Terms

Atypical hemolytic uremic syndrome with an identified genetic cause

Inclusion Terms
  • Atypical (nongenetic) hemolytic uremic syndrome
  • Secondary hemolytic-uremic syndrome
Inclusion Terms
  • Mechanical hemolytic anemia
  • Microangiopathic hemolytic anemia
  • Toxic hemolytic anemia
Inclusion Terms
  • Hemoglobinuria from exertion
  • March hemoglobinuria
  • Paroxysmal cold hemoglobinuria
Inclusion Terms

Idiopathic hemolytic anemia, chronic

Code Also
  • , if applicable, any associated:
  • acute kidney failure (N17.-)
  • chronic kidney disease (N18.-)
Code Also
  • , if applicable:
  • defects in the complement system (D84.1)
  • methylmalonic acidemia (E71.120)
Code Also
  • , if applicable, any associated condition, such as:
  • hypertensive emergency (I16.1)
  • malignant neoplasm (C00-C96)
  • systemic lupus erythematosus (M32.-)

Child Codes (More Specific Codes for D59):

D59.0 - Drug-induced autoimmune hemolytic anemia D59.1 - Other autoimmune hemolytic anemias D59.10 - Autoimmune hemolytic anemia, unspecified D59.11 - Warm autoimmune hemolytic anemia D59.12 - Cold autoimmune hemolytic anemia D59.13 - Mixed type autoimmune hemolytic anemia D59.19 - Other autoimmune hemolytic anemia D59.2 - Drug-induced nonautoimmune hemolytic anemia D59.3 - Hemolytic-uremic syndrome D59.30 - Hemolytic-uremic syndrome, unspecified D59.31 - Infection-associated hemolytic-uremic syndrome D59.32 - Hereditary hemolytic-uremic syndrome D59.39 - Other hemolytic-uremic syndrome D59.4 - Other nonautoimmune hemolytic anemias D59.5 - Paroxysmal nocturnal hemoglobinuria [Marchiafava-Micheli] D59.6 - Hemoglobinuria due to hemolysis from other external causes D59.8 - Other acquired hemolytic anemias D59.9 - Acquired hemolytic anemia, unspecified

About ICD-10-CM Code D59 (Acquired hemolytic anemia)

ICD-10-CM code D59 is a billable or specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes. The 2025 edition of ICD-10-CM D59 became effective on October 1, 2024.

This page provides detailed information about D59 - Acquired hemolytic anemia. It includes common terminology, coding guidelines such as "Includes," "Excludes1," and "Excludes2" notes, and information on required 7th characters. Utilizing this information correctly is essential for accurate medical coding and claims submission for conditions like Acquired hemolytic anemia.