ICD-10-CM D59.3: Hemolytic-uremic syndrome

ICD-10-CM Diagnosis Code (2025)

Official Description for D59.3

Hemolytic-uremic syndrome

Coding Notes & Guidelines for D59.3

Code First
  • , if applicable, any associated:
  • COVID-19 (U07.1)
  • complications of kidney transplant (T86.1-)
  • complications of heart transplant (T86.2-)
  • complications of liver transplant (T86.4-)
Use Additional Code
  • code to identify associated infection, such as :
  • E. coli infection (B96.2-)
  • Human immunodeficiency virus [HIV] disease (B20)
  • Pneumococcal meningitis (G00.1)
  • Pneumococcal pneumonia (J13)
  • Sepsis due to Streptococcus pneumoniae (A40.3)
  • Shigella dysenteriae (A03.9)
  • Streptococcus pneumoniae as the cause of diseases classified elsewhere (B95.3)
Use Additional Code

code, if applicable, for adverse effect to identify drug (T36-T50 with fifth or sixth character 5)

Inclusion Terms

Hemolytic-uremic syndrome NOS

Inclusion Terms
  • Shiga toxin-producing E. coli [STEC] related hemolytic uremic syndrome
  • Typical hemolytic uremic syndrome
Inclusion Terms

Atypical hemolytic uremic syndrome with an identified genetic cause

Inclusion Terms
  • Atypical (nongenetic) hemolytic uremic syndrome
  • Secondary hemolytic-uremic syndrome
Code Also
  • , if applicable, any associated:
  • acute kidney failure (N17.-)
  • chronic kidney disease (N18.-)
Code Also
  • , if applicable:
  • defects in the complement system (D84.1)
  • methylmalonic acidemia (E71.120)
Code Also
  • , if applicable, any associated condition, such as:
  • hypertensive emergency (I16.1)
  • malignant neoplasm (C00-C96)
  • systemic lupus erythematosus (M32.-)

Parent Code (Less Specific):

D59 - Acquired hemolytic anemia

About ICD-10-CM Code D59.3 (Hemolytic-uremic syndrome)

ICD-10-CM code D59.3 is a billable or specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes. The 2025 edition of ICD-10-CM D59.3 became effective on October 1, 2024.

This page provides detailed information about D59.3 - Hemolytic-uremic syndrome. It includes common terminology, coding guidelines such as "Includes," "Excludes1," and "Excludes2" notes, and information on required 7th characters. Utilizing this information correctly is essential for accurate medical coding and claims submission for conditions like Hemolytic-uremic syndrome.