ICD-10-CM D89: Other disorders involving the immune mechanism, not elsewhere classified

ICD-10-CM Diagnosis Code (2025)

Official Description for D89

Other disorders involving the immune mechanism, not elsewhere classified

Coding Notes & Guidelines for D89

Excludes1: Not Coded Here
  • hyperglobulinemia NOS (R77.1)
  • monoclonal gammopathy (of undetermined significance) (D47.2)
Excludes1: Not Coded Here
  • aggressive systemic mastocytosis (C96.21)
  • congenital cutaneous mastocytosis (Q82.2)
  • (non-congenital) cutaneous mastocytosis (D47.01)
  • (indolent) systemic mastocytosis (D47.02)
  • malignant mast cell neoplasm (C96.2-)
  • malignant mastocytoma (C96.29)
  • mast cell leukemia (C94.3-)
  • mast cell sarcoma (C96.22)
  • mastocytoma NOS (D47.09)
  • other mast cell neoplasms of uncertain behavior (D47.09)
  • systemic mastocytosis associated with a clonal hematologic non-mast cell lineage disease (SM-AHNMD) (D47.02)
Excludes1: Not Coded Here

human immunodeficiency virus disease (B20)

Excludes2: Not Included Here

transplant failure and rejection (T86.-)

Code First
  • underlying cause, such as:
  • complications of transplanted organs and tissue (T86.-)
  • complications of blood transfusion (T80.89)
Code First
  • underlying cause, such as:
  • complications following infusion, transfusion and therapeutic injection (T80.89-)
  • complications of transplanted organs and tissue (T86.-)
Use Additional Code

code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)

Use Additional Code
  • code, if applicable, for:
  • allergy status, other than to drugs and biological substances (Z91.0-)
  • personal history of anaphylaxis (Z87.892)
Use Additional Code
  • code to identify associated manifestations, such as:
  • desquamative dermatitis (L30.8)
  • diarrhea (R19.7)
  • elevated bilirubin (R17)
  • hair loss (L65.9)
Use Additional Code

code for adverse effect, if applicable, to identify immune checkpoint inhibitors and immunostimulant drugs (T45.AX5)

Use Additional Code

code to identify associated manifestations

Inclusion Terms
  • Benign hypergammaglobulinemic purpura
  • Polyclonal gammopathy NOS
Inclusion Terms
  • Cryoglobulinemic purpura
  • Cryoglobulinemic vasculitis
  • Essential cryoglobulinemia
  • Idiopathic cryoglobulinemia
  • Mixed cryoglobulinemia
  • Primary cryoglobulinemia
  • Secondary cryoglobulinemia
Inclusion Terms

Immune reconstitution inflammatory syndrome [IRIS]

Inclusion Terms
  • Mast cell activation disorder, unspecified
  • Mast cell activation syndrome, NOS
Inclusion Terms

Secondary mast cell activation syndrome

Inclusion Terms

Other mast cell activation syndrome

Inclusion Terms

Immunoglobulin G4-related disease

Inclusion Terms

Immune disease NOS

Code Also

underlying etiology, if known

Child Codes (More Specific Codes for D89):

D89.0 - Polyclonal hypergammaglobulinemia D89.1 - Cryoglobulinemia D89.2 - Hypergammaglobulinemia, unspecified D89.3 - Immune reconstitution syndrome D89.4 - Mast cell activation syndrome and related disorders D89.40 - Mast cell activation, unspecified D89.41 - Monoclonal mast cell activation syndrome D89.42 - Idiopathic mast cell activation syndrome D89.43 - Secondary mast cell activation D89.44 - Hereditary alpha tryptasemia D89.49 - Other mast cell activation disorder D89.8 - Other specified disorders involving the immune mechanism, not elsewhere classified D89.81 - Graft-versus-host disease D89.810 - Acute graft-versus-host disease D89.811 - Chronic graft-versus-host disease D89.812 - Acute on chronic graft-versus-host disease D89.813 - Graft-versus-host disease, unspecified D89.82 - Autoimmune lymphoproliferative syndrome [ALPS] D89.83 - Cytokine release syndrome D89.831 - Cytokine release syndrome, grade 1 D89.832 - Cytokine release syndrome, grade 2 D89.833 - Cytokine release syndrome, grade 3 D89.834 - Cytokine release syndrome, grade 4 D89.835 - Cytokine release syndrome, grade 5 D89.839 - Cytokine release syndrome, grade unspecified D89.84 - IgG4-related disease D89.89 - Other specified disorders involving the immune mechanism, not elsewhere classified D89.9 - Disorder involving the immune mechanism, unspecified

About ICD-10-CM Code D89 (Other disorders involving the immune mechanism)

ICD-10-CM code D89 is a billable or specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes. The 2025 edition of ICD-10-CM D89 became effective on October 1, 2024.

This page provides detailed information about D89 - Other disorders involving the immune mechanism, not elsewhere classified. It includes common terminology, coding guidelines such as "Includes," "Excludes1," and "Excludes2" notes, and information on required 7th characters. Utilizing this information correctly is essential for accurate medical coding and claims submission for conditions like Other disorders involving the immune mechanism related to not elsewhere classified.