ICD-10-CM E16: Other disorders of pancreatic internal secretion

ICD-10-CM Diagnosis Code (2025)

Official Description for E16

Other disorders of pancreatic internal secretion

Coding Notes & Guidelines for E16

Excludes1: Not Coded Here

diabetes with hypoglycemia without coma (E09.649)

Excludes1: Not Coded Here
  • diabetes with hypoglycemia (E08.649, E10.649, E11.649, E13.649)
  • hypoglycemia in infant of diabetic mother (P70.1)
  • neonatal hypoglycemia (P70.4)
Excludes1: Not Coded Here

diabetes with hypoglycemia (E08.649, E10.649, E11.649, E13.649)

Use Additional Code

code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)

Use Additional Code

code for hypoglycemia level, if applicable (E16.A-)

Use Additional Code

code for hypoglycemia level, if applicable (E16.A-)

Use Additional Code

code for hypoglycemia level, if applicable (E16.A-)

Inclusion Terms
  • Functional hyperinsulinism
  • Functional nonhyperinsulinemic hypoglycemia
  • Hyperinsulinism NOS
  • Hyperplasia of pancreatic islet beta cells NOS
Inclusion Terms

Hyperplasia of pancreatic endocrine cells with glucagon excess

Inclusion Terms
  • Hypergastrinemia
  • Hyperplasia of pancreatic endocrine cells with gastrin excess
  • Zollinger-Ellison syndrome
Inclusion Terms
  • Increased secretion from endocrine pancreas of growth hormone-releasing hormone
  • Increased secretion from endocrine pancreas of pancreatic polypeptide
  • Increased secretion from endocrine pancreas of somatostatin
  • Increased secretion from endocrine pancreas of vasoactive-intestinal polypeptide
Inclusion Terms
  • Islet-cell hyperplasia NOS
  • Pancreatic endocrine cell hyperplasia NOS
Inclusion Terms

Decreased blood glucose level 1

Inclusion Terms

Decreased blood glucose level 2

Inclusion Terms

Decreased blood glucose level 3

Child Codes (More Specific Codes for E16):

E16.0 - Drug-induced hypoglycemia without coma E16.1 - Other hypoglycemia E16.2 - Hypoglycemia, unspecified E16.3 - Increased secretion of glucagon E16.4 - Increased secretion of gastrin E16.8 - Other specified disorders of pancreatic internal secretion E16.9 - Disorder of pancreatic internal secretion, unspecified E16.A - Hypoglycemia level E16.A1 - Hypoglycemia level 1 E16.A2 - Hypoglycemia level 2 E16.A3 - Hypoglycemia level 3

About ICD-10-CM Code E16 (Other disorders of pancreatic internal secretion)

ICD-10-CM code E16 is a billable or specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes. The 2025 edition of ICD-10-CM E16 became effective on October 1, 2024.

This page provides detailed information about E16 - Other disorders of pancreatic internal secretion. It includes common terminology, coding guidelines such as "Includes," "Excludes1," and "Excludes2" notes, and information on required 7th characters. Utilizing this information correctly is essential for accurate medical coding and claims submission for conditions like Other disorders of pancreatic internal secretion.