ICD-10-CM E88: Other and unspecified metabolic disorders

ICD-10-CM Diagnosis Code (2025)

Official Description for E88

Other and unspecified metabolic disorders

Coding Notes & Guidelines for E88

Excludes1: Not Coded Here

histiocytosis X (chronic) (C96.6)

Excludes1: Not Coded Here
  • monoclonal gammopathy (of undetermined significance) (D47.2)
  • polyclonal hypergammaglobulinemia (D89.0)
  • Waldenström macroglobulinemia (C88.00)
Excludes1: Not Coded Here

Whipple's disease (K90.81)

Excludes1: Not Coded Here
  • disorders of pyruvate metabolism (E74.4)
  • Kearns-Sayre syndrome (H49.81)
  • Leber's disease (H47.22)
  • Leigh's encephalopathy (G31.82)
  • Mitochondrial myopathy, NEC (G71.3)
  • Reye's syndrome (G93.7)
Excludes1: Not Coded Here

adult pulmonary Langerhans cell histiocytosis (J84.82)

Excludes1: Not Coded Here
  • cachexia NOS (R64)
  • nutritional marasmus (E41)
Excludes2: Not Included Here

disorder of lipoprotein metabolism (E78.-)

Excludes2: Not Included Here

failure to thrive (R62.51, R62.7)

Code First

underlying condition

Use Additional Code

codes for associated conditions

Use Additional Code
  • code for associated findings, such as:
  • hydrocephalus (G91.4)
  • otitis media (H67.-)
  • respiratory disorder related to plasminogen deficiency (J99)
Use Additional Code

code for adverse effect, if applicable, to identify drug (T45.1X5)

Use Additional Code
  • codes for associated manifestations, such as:
  • obesity (E66.-)
Use Additional Code

code, if applicable, to identify associated manifestations, such as polyphagia (R63.2)

Use Additional Code

code to identify body mass index (BMI), if known (Z68.-)

Inclusion Terms

AAT deficiency

Inclusion Terms
  • Dysplasminogenemia
  • Hypoplasminogenemia
  • Type 1 plasminogen deficiency
  • Type 2 plasminogen deficiency
Inclusion Terms

Bisalbuminemia

Inclusion Terms

Lipodystrophy NOS

Inclusion Terms
  • Lipomatosis NOS
  • Lipomatosis (Check) dolorosa [Dercum]
Inclusion Terms
  • Tumor lysis syndrome (spontaneous)
  • Tumor lysis syndrome following antineoplastic drug chemotherapy
Inclusion Terms

Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes

Inclusion Terms

Myoclonic epilepsy associated with ragged-red fibers

Inclusion Terms

Dysmetabolic syndrome

Inclusion Terms

Insulin resistance syndrome, Type B

Inclusion Terms

Launois-Bensaude adenolipomatosis

Inclusion Terms

Cachexia due to underlying condition

Code Also

, if applicable, ligneous conjunctivitis (H10.51)

Code Also

progressive myoclonic epilepsy (G40.3-)

Child Codes (More Specific Codes for E88):

E88.0 - Disorders of plasma-protein metabolism, not elsewhere classified E88.01 - Alpha-1-antitrypsin deficiency E88.02 - Plasminogen deficiency E88.09 - Other disorders of plasma-protein metabolism, not elsewhere classified E88.1 - Lipodystrophy, not elsewhere classified E88.2 - Lipomatosis, not elsewhere classified E88.3 - Tumor lysis syndrome E88.4 - Mitochondrial metabolism disorders E88.40 - Mitochondrial metabolism disorder, unspecified E88.41 - MELAS syndrome E88.42 - MERRF syndrome E88.43 - Disorders of mitochondrial tRNA synthetases E88.49 - Other mitochondrial metabolism disorders E88.8 - Other specified metabolic disorders E88.81 - Metabolic syndrome and other insulin resistance E88.810 - Metabolic syndrome E88.811 - Insulin resistance syndrome, Type A E88.818 - Other insulin resistance E88.819 - Insulin resistance, unspecified E88.82 - Obesity due to disruption of MC4R pathway E88.89 - Other specified metabolic disorders E88.9 - Metabolic disorder, unspecified E88.A - Wasting disease (syndrome) due to underlying condition

About ICD-10-CM Code E88 (Other and unspecified metabolic disorders)

ICD-10-CM code E88 is a billable or specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes. The 2025 edition of ICD-10-CM E88 became effective on October 1, 2024.

This page provides detailed information about E88 - Other and unspecified metabolic disorders. It includes common terminology, coding guidelines such as "Includes," "Excludes1," and "Excludes2" notes, and information on required 7th characters. Utilizing this information correctly is essential for accurate medical coding and claims submission for conditions like Other and unspecified metabolic disorders.