ICD-10-CM I21: Acute myocardial infarction

ICD-10-CM Diagnosis Code (2025)

Official Description for I21

Acute myocardial infarction

Coding Notes & Guidelines for I21

Includes Notes
  • cardiac infarction
  • coronary (artery) embolism
  • coronary (artery) occlusion
  • coronary (artery) rupture
  • coronary (artery) thrombosis
  • infarction of heart, myocardium, or ventricle
  • myocardial infarction specified as acute or with a stated duration of 4 weeks (28 days) or less from onset
Excludes2: Not Included Here
  • old myocardial infarction (I25.2)
  • postmyocardial infarction syndrome (I24.1)
  • subsequent type 1 myocardial infarction (I22.-)
Excludes2: Not Included Here

ST elevation (STEMI) myocardial infarction involving left circumflex coronary artery (I21.21)

Code First
  • , if applicable, the underlying cause, such as:
  • anemia (D50.0-D64.9)
  • chronic obstructive pulmonary disease (J44.-)
  • paroxysmal tachycardia (I47.0-I47.9)
  • shock (R57.0-R57.9)
Code First

, if applicable, postprocedural myocardial infarction following cardiac surgery (I97.190), or postprocedural myocardial infarction during cardiac surgery (I97.790)

Use Additional Code
  • code, if applicable, to identify:
  • exposure to environmental tobacco smoke (Z77.22)
  • history of tobacco dependence (Z87.891)
  • occupational exposure to environmental tobacco smoke (Z57.31)
  • status post administration of tPA (rtPA) in a different facility within the last 24 hours prior to admission to current facility (Z92.82)
  • tobacco dependence (F17.-)
  • tobacco use (Z72.0)
Inclusion Terms

Type 1 ST elevation myocardial infarction of anterior wall

Inclusion Terms

ST elevation (STEMI) myocardial infarction involving diagonal coronary artery

Inclusion Terms
  • Acute transmural myocardial infarction of anterior wall
  • Anteroapical transmural (Q wave) infarction (acute)
  • Anterolateral transmural (Q wave) infarction (acute)
  • Anteroseptal transmural (Q wave) infarction (acute)
  • Transmural (Q wave) infarction (acute) (of) anterior (wall) NOS
Inclusion Terms

Type 1 ST elevation myocardial infarction of inferior wall

Inclusion Terms

Inferoposterior transmural (Q wave) infarction (acute)

Inclusion Terms
  • Acute transmural myocardial infarction of inferior wall
  • Inferolateral transmural (Q wave) infarction (acute)
  • Transmural (Q wave) infarction (acute) (of) diaphragmatic wall
  • Transmural (Q wave) infarction (acute) (of) inferior (wall) NOS
Inclusion Terms

Type 1 ST elevation myocardial infarction of other sites

Inclusion Terms

ST elevation (STEMI) myocardial infarction involving oblique marginal coronary artery

Inclusion Terms
  • Acute transmural myocardial infarction of other sites
  • Apical-lateral transmural (Q wave) infarction (acute)
  • Basal-lateral transmural (Q wave) infarction (acute)
  • High lateral transmural (Q wave) infarction (acute)
  • Lateral (wall) NOS transmural (Q wave) infarction (acute)
  • Posterior (true) transmural (Q wave) infarction (acute)
  • Posterobasal transmural (Q wave) infarction (acute)
  • Posterolateral transmural (Q wave) infarction (acute)
  • Posteroseptal transmural (Q wave) infarction (acute)
  • Septal transmural (Q wave) infarction (acute) NOS
Inclusion Terms
  • Acute transmural myocardial infarction of unspecified site
  • Transmural (Q wave) myocardial infarction NOS
  • Type 1 ST elevation myocardial infarction of unspecified site
Inclusion Terms
  • Acute subendocardial myocardial infarction
  • Non-Q wave myocardial infarction NOS
  • Nontransmural myocardial infarction NOS
  • Type 1 non-ST elevation myocardial infarction
Inclusion Terms

Myocardial infarction (acute) NOS

Inclusion Terms
  • Myocardial infarction due to demand ischemia
  • Myocardial infarction secondary to ischemic imbalance
Inclusion Terms
  • Myocardial infarction associated with revascularization procedure
  • Myocardial infarction type 3
  • Myocardial infarction type 4a
  • Myocardial infarction type 4b
  • Myocardial infarction type 4c
  • Myocardial infarction type 5
Inclusion Terms
  • Myocardial infarction with coronary microvascular disease
  • Myocardial infarction with nonobstructive coronary arteries [MINOCA] with microvascular disease
Code Also
  • complication, if known and applicable, such as:
  • (acute) stent occlusion (T82.897-)
  • (acute) stent stenosis (T82.855-)
  • (acute) stent thrombosis (T82.867-)
  • cardiac arrest due to underlying cardiac condition (I46.2)
  • complication of percutaneous coronary intervention (PCI) (I97.89)
  • occlusion of coronary artery bypass graft (T82.218-)

Child Codes (More Specific Codes for I21):

About ICD-10-CM Code I21 (Acute myocardial infarction)

ICD-10-CM code I21 is a billable or specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes. The 2025 edition of ICD-10-CM I21 became effective on October 1, 2024.

This page provides detailed information about I21 - Acute myocardial infarction. It includes common terminology, coding guidelines such as "Includes," "Excludes1," and "Excludes2" notes, and information on required 7th characters. Utilizing this information correctly is essential for accurate medical coding and claims submission for conditions like Acute myocardial infarction.