ICD-10-CM M35.81: Multisystem inflammatory syndrome

ICD-10-CM Diagnosis Code (2025)

Official Description for M35.81

Multisystem inflammatory syndrome

Coding Notes & Guidelines for M35.81

Code First

, if applicable, COVID-19 (U07.1)

Use Additional Code
  • code, if applicable, for:
  • exposure to COVID-19 or SARS-CoV-2 infection (Z20.822)
  • personal history of COVID-19 (Z86.16)
  • post COVID-19 condition (U09.9)
Inclusion Terms
  • MIS-A
  • MIS-C
  • Multisystem inflammatory syndrome in adults
  • Multisystem inflammatory syndrome in children
  • Pediatric inflammatory multisystem syndrome
  • PIMS
Code Also
  • any associated complications such as:
  • acute hepatic failure (K72.0-)
  • acute kidney failure (N17.-)
  • acute myocarditis (I40.-)
  • acute respiratory distress syndrome (J80)
  • cardiac arrhythmia (I47-I49.-)
  • pneumonia due to COVID-19 (J12.82)
  • severe sepsis (R65.2-)
  • viral cardiomyopathy (B33.24)
  • viral pericarditis (B33.23)

Parent Code (Less Specific):

About ICD-10-CM Code M35.81 (Multisystem inflammatory syndrome)

ICD-10-CM code M35.81 is a billable or specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes. The 2025 edition of ICD-10-CM M35.81 became effective on October 1, 2024.

This page provides detailed information about M35.81 - Multisystem inflammatory syndrome. It includes common terminology, coding guidelines such as "Includes," "Excludes1," and "Excludes2" notes, and information on required 7th characters. Utilizing this information correctly is essential for accurate medical coding and claims submission for conditions like Multisystem inflammatory syndrome.