ICD-10-CM R53: Malaise and fatigue

ICD-10-CM Diagnosis Code (2025)

Official Description for R53

Malaise and fatigue

Coding Notes & Guidelines for R53

Excludes1: Not Coded Here
  • age-related weakness (R54)
  • muscle weakness (generalized) (M62.81)
  • sarcopenia (M62.84)
  • senile asthenia (R54)
Excludes1: Not Coded Here
  • frailty NOS (R54)
  • hysterical paralysis (F44.4)
  • immobility syndrome (M62.3)
  • neurologic quadriplegia (G82.5-)
  • quadriplegia (G82.50)
Excludes1: Not Coded Here
  • combat exhaustion and fatigue (F43.0)
  • congenital debility (P96.9)
  • exhaustion and fatigue due to excessive exertion (T73.3)
  • exhaustion and fatigue due to exposure (T73.2)
  • exhaustion and fatigue due to heat (T67.-)
  • exhaustion and fatigue due to pregnancy (O26.8-)
  • exhaustion and fatigue due to recurrent depressive episode (F33)
  • exhaustion and fatigue due to senile debility (R54)
Excludes1: Not Coded Here

age-related physical debility (R54)

Excludes1: Not Coded Here
  • chronic fatigue syndrome (G93.32)
  • myalgic encephalomyelitis (G93.32)
  • other post infection and related fatigue syndromes (G93.39)
  • postviral fatigue syndrome (G93.31)
Excludes2: Not Included Here

exhaustion and fatigue due to depressive episode (F32.-)

Code First

associated neoplasm

Inclusion Terms

Asthenia NOS

Inclusion Terms

Complete immobility due to severe physical disability or frailty

Inclusion Terms
  • Chronic debility
  • Debility NOS
  • General physical deterioration
  • Malaise NOS
  • Nervous debility
Inclusion Terms
  • Fatigue NOS
  • Lack of energy
  • Lethargy
  • Tiredness

Child Codes (More Specific Codes for R53):

R53.0 - Neoplastic (malignant) related fatigue R53.1 - Weakness R53.2 - Functional quadriplegia R53.8 - Other malaise and fatigue R53.81 - Other malaise R53.82 - Chronic fatigue, unspecified R53.83 - Other fatigue

About ICD-10-CM Code R53 (Malaise and fatigue)

ICD-10-CM code R53 is a billable or specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes. The 2025 edition of ICD-10-CM R53 became effective on October 1, 2024.

This page provides detailed information about R53 - Malaise and fatigue. It includes common terminology, coding guidelines such as "Includes," "Excludes1," and "Excludes2" notes, and information on required 7th characters. Utilizing this information correctly is essential for accurate medical coding and claims submission for conditions like Malaise and fatigue.