ICD-10-CM R65: Symptoms and signs specifically associated with systemic inflammation and infection

ICD-10-CM Diagnosis Code (2025)

Official Description for R65

Symptoms and signs specifically associated with systemic inflammation and infection

Coding Notes & Guidelines for R65

Excludes1: Not Coded Here
  • sepsis- code to infection
  • severe sepsis (R65.2)
Code First
  • underlying condition, such as:
  • heatstroke (T67.0-)
  • injury and trauma (S00-T88)
Code First
  • underlying infection, such as:
  • infection following a procedure (T81.4-)
  • infections following infusion, transfusion and therapeutic injection (T80.2-)
  • puerperal sepsis (O85)
  • sepsis following complete or unspecified spontaneous abortion (O03.87)
  • sepsis following ectopic and molar pregnancy (O08.82)
  • sepsis following incomplete spontaneous abortion (O03.37)
  • sepsis following (induced) termination of pregnancy (O04.87)
  • sepsis NOS (A41.9)
Use Additional Code
  • code to identify specific acute organ dysfunction, such as:
  • acute kidney failure (N17.-)
  • acute respiratory failure (J96.0-)
  • critical illness myopathy (G72.81)
  • critical illness polyneuropathy (G62.81)
  • disseminated intravascular coagulopathy [DIC] (D65)
  • encephalopathy (metabolic) (septic) (G93.41)
  • hepatic failure (K72.0-)
Use Additional Code
  • code to identify specific acute organ dysfunction, such as:
  • acute kidney failure (N17.-)
  • acute respiratory failure (J96.0-)
  • critical illness myopathy (G72.81)
  • critical illness polyneuropathy (G62.81)
  • disseminated intravascular coagulopathy [DIC] (D65)
  • encephalopathy (metabolic) (septic) (G93.41)
  • hepatic failure (K72.0-)
Inclusion Terms

Systemic inflammatory response syndrome (SIRS) NOS

Inclusion Terms
  • Infection with associated acute organ dysfunction
  • Sepsis with acute organ dysfunction
  • Sepsis with multiple organ dysfunction
  • Systemic inflammatory response syndrome due to infectious process with acute organ dysfunction
Inclusion Terms

Severe sepsis NOS

Child Codes (More Specific Codes for R65):

R65.1 - Systemic inflammatory response syndrome (SIRS) of non-infectious origin R65.10 - Systemic inflammatory response syndrome (SIRS) of non-infectious origin without acute organ dysfunction R65.11 - Systemic inflammatory response syndrome (SIRS) of non-infectious origin with acute organ dysfunction R65.2 - Severe sepsis R65.20 - Severe sepsis without septic shock R65.21 - Severe sepsis with septic shock

About ICD-10-CM Code R65 (Symptoms and signs specifically associated with systemic inflammation and infection)

ICD-10-CM code R65 is a billable or specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes. The 2025 edition of ICD-10-CM R65 became effective on October 1, 2024.

This page provides detailed information about R65 - Symptoms and signs specifically associated with systemic inflammation and infection. It includes common terminology, coding guidelines such as "Includes," "Excludes1," and "Excludes2" notes, and information on required 7th characters. Utilizing this information correctly is essential for accurate medical coding and claims submission for conditions like Symptoms and signs specifically associated with systemic inflammation and infection.