ICD-10-CM R65.11: Systemic inflammatory response syndrome (SIRS) of non-infectious origin with acute organ dysfunction

ICD-10-CM Diagnosis Code (2025)

Official Description for R65.11

Systemic inflammatory response syndrome (SIRS) of non-infectious origin with acute organ dysfunction

Coding Notes & Guidelines for R65.11

Use Additional Code
  • code to identify specific acute organ dysfunction, such as:
  • acute kidney failure (N17.-)
  • acute respiratory failure (J96.0-)
  • critical illness myopathy (G72.81)
  • critical illness polyneuropathy (G62.81)
  • disseminated intravascular coagulopathy [DIC] (D65)
  • encephalopathy (metabolic) (septic) (G93.41)
  • hepatic failure (K72.0-)

Parent Code (Less Specific):

About ICD-10-CM Code R65.11 (Systemic inflammatory response syndrome)

ICD-10-CM code R65.11 is a billable or specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes. The 2025 edition of ICD-10-CM R65.11 became effective on October 1, 2024.

This page provides detailed information about R65.11 - Systemic inflammatory response syndrome (SIRS) of non-infectious origin with acute organ dysfunction. It includes common terminology, coding guidelines such as "Includes," "Excludes1," and "Excludes2" notes, and information on required 7th characters. Utilizing this information correctly is essential for accurate medical coding and claims submission for conditions like Systemic inflammatory response syndrome.