ICD-10-CM R65.2: Severe sepsis

ICD-10-CM Diagnosis Code (2025)

Official Description for R65.2

Severe sepsis

Coding Notes & Guidelines for R65.2

Code First
  • underlying infection, such as:
  • infection following a procedure (T81.4-)
  • infections following infusion, transfusion and therapeutic injection (T80.2-)
  • puerperal sepsis (O85)
  • sepsis following complete or unspecified spontaneous abortion (O03.87)
  • sepsis following ectopic and molar pregnancy (O08.82)
  • sepsis following incomplete spontaneous abortion (O03.37)
  • sepsis following (induced) termination of pregnancy (O04.87)
  • sepsis NOS (A41.9)
Use Additional Code
  • code to identify specific acute organ dysfunction, such as:
  • acute kidney failure (N17.-)
  • acute respiratory failure (J96.0-)
  • critical illness myopathy (G72.81)
  • critical illness polyneuropathy (G62.81)
  • disseminated intravascular coagulopathy [DIC] (D65)
  • encephalopathy (metabolic) (septic) (G93.41)
  • hepatic failure (K72.0-)
Inclusion Terms
  • Infection with associated acute organ dysfunction
  • Sepsis with acute organ dysfunction
  • Sepsis with multiple organ dysfunction
  • Systemic inflammatory response syndrome due to infectious process with acute organ dysfunction
Inclusion Terms

Severe sepsis NOS

Parent Code (Less Specific):

R65 - Symptoms and signs specifically associated with systemic inflammation and infection

About ICD-10-CM Code R65.2 (Severe sepsis)

ICD-10-CM code R65.2 is a billable or specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes. The 2025 edition of ICD-10-CM R65.2 became effective on October 1, 2024.

This page provides detailed information about R65.2 - Severe sepsis. It includes common terminology, coding guidelines such as "Includes," "Excludes1," and "Excludes2" notes, and information on required 7th characters. Utilizing this information correctly is essential for accurate medical coding and claims submission for conditions like Severe sepsis.