ICD-10-CM T80: Complications following infusion, transfusion and therapeutic injection

ICD-10-CM Diagnosis Code (2025)

Official Description for T80

Complications following infusion, transfusion and therapeutic injection

Coding Notes & Guidelines for T80

Includes Notes

complications following perfusion

Excludes1: Not Coded Here

minor blood group antigens reactions (Duffy) (E) (K) (Kell) (Kidd) (Lewis) (M) (N) (P) (S) (T80.A-)

Excludes1: Not Coded Here
  • ABO incompatibility reaction due to transfusion of blood or blood products (T80.3-)
  • allergic reaction or shock NOS (T78.2)
  • anaphylactic reaction or shock NOS (T78.2)
  • anaphylactic reaction or shock due to adverse effect of correct medicinal substance properly administered (T88.6)
  • other serum reaction (T80.6-)
Excludes1: Not Coded Here
  • ABO incompatibility with hemolytic transfusion reaction (T80.31-)
  • Non-ABO incompatibility with hemolytic transfusion reaction (T80.A1-)
  • Rh incompatibility with hemolytic transfusion reaction (T80.41-)
Excludes2: Not Included Here
  • bone marrow transplant rejection (T86.01)
  • febrile nonhemolytic transfusion reaction (R50.84)
  • fluid overload due to transfusion (E87.71)
  • posttransfusion purpura (D69.51)
  • transfusion associated circulatory overload (TACO) (E87.71)
  • transfusion (red blood cell) associated hemochromatosis (E83.111)
  • transfusion related acute lung injury (TRALI) (J95.84)
Excludes2: Not Included Here
  • extravasation of vesicant agent (T80.81-)
  • infiltration of vesicant agent (T80.81-)
  • vascular complications specified as due to prosthetic devices, implants and grafts (T82.8-, T83.8-, T84.8-, T85.8-)
  • postprocedural vascular complications (T81.7-)
Excludes2: Not Included Here
  • infections specified as due to prosthetic devices, implants and grafts (T82.6-T82.7, T83.5-T83.6, T84.5-T84.7, T85.7)
  • postprocedural infections (T81.4-)
Excludes2: Not Included Here

serum hepatitis (B16-B19)

Excludes2: Not Included Here
  • adverse effect of immune checkpoint inhibitors and immunostimulant drugs (T45.AX5)
  • complication of bone marrow transplant (T86.0)
  • complication of stem cell transplant (T86.5)
Use Additional Code

code to identify the vascular complication

Use Additional Code
  • code to identify the specific infection, such as:
  • sepsis (A41.9)
Use Additional Code

code (R65.2-) to identify severe sepsis, if applicable

Use Additional Code
  • code to identify the specific complication, such as:
  • cytokine release syndrome (D89.83-)
  • immune effector cell-associated neurotoxicity syndrome (G92.0-)
Use Additional Code

code to identify graft-versus-host reaction, if applicable, (D89.81-)

Inclusion Terms

Infection due to pulmonary artery catheter (Swan-Ganz catheter)

Inclusion Terms
  • Catheter-related bloodstream infection (CRBSI) NOS
  • Central line-associated bloodstream infection (CLABSI)
  • Bloodstream infection due to Hickman catheter
  • Bloodstream infection due to peripherally inserted central catheter (PICC)
  • Bloodstream infection due to portacath (port-a-cath)
  • Bloodstream infection due to pulmonary artery catheter
  • Bloodstream infection due to triple lumen catheter
  • Bloodstream infection due to umbilical venous catheter
Inclusion Terms
  • Exit or insertion site infection
  • Local infection due to Hickman catheter
  • Local infection due to peripherally inserted central catheter (PICC)
  • Local infection due to portacath (port-a-cath)
  • Local infection due to pulmonary artery catheter
  • Local infection due to triple lumen catheter
  • Local infection due to umbilical venous catheter
  • Port or reservoir infection
  • Tunnel infection
Inclusion Terms
  • Other central line-associated infection
  • Other infection due to Hickman catheter
  • Other infection due to peripherally inserted central catheter (PICC)
  • Other infection due to portacath (port-a-cath)
  • Other infection due to pulmonary artery catheter
  • Other infection due to triple lumen catheter
  • Other infection due to umbilical venous catheter
Inclusion Terms
  • Central line-associated infection NOS
  • Unspecified infection due to Hickman catheter
  • Unspecified infection due to peripherally inserted central catheter (PICC)
  • Unspecified infection due to portacath (port-a-cath)
  • Unspecified infection due to pulmonary artery catheter
  • Unspecified infection due to triple lumen catheter
  • Unspecified infection due to umbilical venous catheter
Inclusion Terms
  • ABO incompatibility blood transfusion NOS
  • Reaction to ABO incompatibility from transfusion NOS
Inclusion Terms
  • ABO incompatibility with hemolytic transfusion reaction less than 24 hours after transfusion
  • Acute hemolytic transfusion reaction (AHTR) due to ABO incompatibility
Inclusion Terms
  • ABO incompatibility with hemolytic transfusion reaction 24 hours or more after transfusion
  • Delayed hemolytic transfusion reaction (DHTR) due to ABO incompatibility
Inclusion Terms
  • ABO incompatibility with hemolytic transfusion reaction at unspecified time after transfusion
  • Hemolytic transfusion reaction (HTR) due to ABO incompatibility NOS
Inclusion Terms
  • Delayed serologic transfusion reaction (DSTR) from ABO incompatibility
  • Other ABO incompatible blood transfusion
  • Other reaction to ABO incompatible blood transfusion
Inclusion Terms

Reaction due to incompatibility of Rh antigens (C) (c) (D) (E) (e)

Inclusion Terms
  • Reaction due to Rh factor in transfusion NOS
  • Rh incompatible blood transfusion NOS
Inclusion Terms
  • Acute hemolytic transfusion reaction (AHTR) due to Rh incompatibility
  • Rh incompatibility with hemolytic transfusion reaction less than 24 hours after transfusion
Inclusion Terms
  • Delayed hemolytic transfusion reaction (DHTR) due to Rh incompatibility
  • Rh incompatibility with hemolytic transfusion reaction 24 hours or more after transfusion
Inclusion Terms
  • Rh incompatibility with hemolytic transfusion reaction at unspecified time after transfusion
  • Hemolytic transfusion reaction (HTR) due to Rh incompatibility NOS
Inclusion Terms
  • Delayed serologic transfusion reaction (DSTR) from Rh incompatibility
  • Other reaction to Rh incompatible blood transfusion
Inclusion Terms

Reaction due to incompatibility of minor antigens (Duffy) (Kell) (Kidd) (Lewis) (M) (N) (P) (S)

Inclusion Terms

Non-ABO antigen incompatibility reaction from transfusion NOS

Inclusion Terms
  • Acute hemolytic transfusion reaction (AHTR) due to non-ABO incompatibility
  • Non-ABO incompatibility with hemolytic transfusion reaction less than 24 hours after transfusion
Inclusion Terms
  • Delayed hemolytic transfusion reaction (DHTR) due to non-ABO incompatibility
  • Non-ABO incompatibility with hemolytic transfusion reaction 24 or more hours after transfusion
Inclusion Terms
  • Hemolytic transfusion reaction (HTR) due to non-ABO incompatibility NOS
  • Non-ABO incompatibility with hemolytic transfusion reaction at unspecified time after transfusion
Inclusion Terms
  • Delayed serologic transfusion reaction (DSTR) from non-ABO incompatibility
  • Other reaction to non-ABO incompatible blood transfusion
Inclusion Terms
  • Allergic shock due to serum
  • Anaphylactic shock due to serum
  • Anaphylactoid reaction due to serum
  • Anaphylaxis due to serum
Inclusion Terms
  • Intoxication by serum
  • Protein sickness
  • Serum rash
  • Serum sickness
  • Serum urticaria
Inclusion Terms

Infiltration of vesicant agent

Inclusion Terms

Infiltration of vesicant antineoplastic chemotherapy

Inclusion Terms

Infiltration of other vesicant agent

Inclusion Terms
  • Complication of chimeric antigen receptor (CAR-T) cell therapy
  • Complication of IEC therapy
Inclusion Terms

Delayed serologic transfusion reaction (DSTR), unspecified incompatibility

Inclusion Terms

Hemolytic transfusion reaction NOS

Inclusion Terms

Transfusion reaction NOS

Code Also

, if applicable, arthropathy in hypersensitivity reactions classified elsewhere (M36.4)

7th Character Guidance

The appropriate 7th character is to be added to each code from category T80

7th Character Definitions
  • A: initial encounter
  • D: subsequent encounter
  • S: sequela

Child Codes (More Specific Codes for T80):

T80.0 - Air embolism following infusion, transfusion and therapeutic injection T80.1 - Vascular complications following infusion, transfusion and therapeutic injection T80.2 - Infections following infusion, transfusion and therapeutic injection T80.21 - Infection due to central venous catheter T80.211 - Bloodstream infection due to central venous catheter T80.212 - Local infection due to central venous catheter T80.218 - Other infection due to central venous catheter T80.219 - Unspecified infection due to central venous catheter T80.22 - Acute infection following transfusion, infusion, or injection of blood and blood products T80.29 - Infection following other infusion, transfusion and therapeutic injection T80.3 - ABO incompatibility reaction due to transfusion of blood or blood products T80.30 - ABO incompatibility reaction due to transfusion of blood or blood products, unspecified T80.31 - ABO incompatibility with hemolytic transfusion reaction T80.310 - ABO incompatibility with acute hemolytic transfusion reaction T80.311 - ABO incompatibility with delayed hemolytic transfusion reaction T80.319 - ABO incompatibility with hemolytic transfusion reaction, unspecified T80.39 - Other ABO incompatibility reaction due to transfusion of blood or blood products T80.4 - Rh incompatibility reaction due to transfusion of blood or blood products T80.40 - Rh incompatibility reaction due to transfusion of blood or blood products, unspecified T80.41 - Rh incompatibility with hemolytic transfusion reaction T80.410 - Rh incompatibility with acute hemolytic transfusion reaction T80.411 - Rh incompatibility with delayed hemolytic transfusion reaction T80.419 - Rh incompatibility with hemolytic transfusion reaction, unspecified T80.49 - Other Rh incompatibility reaction due to transfusion of blood or blood products T80.5 - Anaphylactic reaction due to serum T80.51 - Anaphylactic reaction due to administration of blood and blood products T80.52 - Anaphylactic reaction due to vaccination T80.59 - Anaphylactic reaction due to other serum T80.6 - Other serum reactions T80.61 - Other serum reaction due to administration of blood and blood products T80.62 - Other serum reaction due to vaccination T80.69 - Other serum reaction due to other serum T80.8 - Other complications following infusion, transfusion and therapeutic injection T80.81 - Extravasation of vesicant agent T80.810 - Extravasation of vesicant antineoplastic chemotherapy T80.818 - Extravasation of other vesicant agent T80.82 - Complication of immune effector cellular therapy T80.89 - Other complications following infusion, transfusion and therapeutic injection T80.9 - Unspecified complication following infusion, transfusion and therapeutic injection T80.90 - Unspecified complication following infusion and therapeutic injection T80.91 - Hemolytic transfusion reaction, unspecified incompatibility T80.910 - Acute hemolytic transfusion reaction, unspecified incompatibility T80.911 - Delayed hemolytic transfusion reaction, unspecified incompatibility T80.919 - Hemolytic transfusion reaction, unspecified incompatibility, unspecified as acute or delayed T80.92 - Unspecified transfusion reaction T80.A - Non-ABO incompatibility reaction due to transfusion of blood or blood products T80.A0 - Non-ABO incompatibility reaction due to transfusion of blood or blood products, unspecified T80.A1 - Non-ABO incompatibility with hemolytic transfusion reaction T80.A10 - Non-ABO incompatibility with acute hemolytic transfusion reaction T80.A11 - Non-ABO incompatibility with delayed hemolytic transfusion reaction T80.A19 - Non-ABO incompatibility with hemolytic transfusion reaction, unspecified T80.A9 - Other non-ABO incompatibility reaction due to transfusion of blood or blood products

About ICD-10-CM Code T80 (Complications following infusion)

ICD-10-CM code T80 is a billable or specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes. The 2025 edition of ICD-10-CM T80 became effective on October 1, 2024.

This page provides detailed information about T80 - Complications following infusion, transfusion and therapeutic injection. It includes common terminology, coding guidelines such as "Includes," "Excludes1," and "Excludes2" notes, and information on required 7th characters. Utilizing this information correctly is essential for accurate medical coding and claims submission for conditions like Complications following infusion related to transfusion and therapeutic injection.