ICD-10-CM Z15: Genetic susceptibility to disease

ICD-10-CM Diagnosis Code (2025)

Official Description for Z15

Genetic susceptibility to disease

Coding Notes & Guidelines for Z15

Includes Notes

confirmed abnormal gene

Excludes1: Not Coded Here

chromosomal anomalies (Q90-Q99)

Excludes1: Not Coded Here

multiple endocrine neoplasia [MEN] syndromes (E31.2-)

Code First

, if applicable, any current malignant neoplasm (C00-C75, C81-C96)

Use Additional Code

code, if applicable, for any associated family history of the disease (Z80-Z84)

Use Additional Code

code, if applicable, for any personal history of malignant neoplasm (Z85.-)

Use Additional Code

code to identify body mass index (BMI), if known (Z68.-)

Code Also
  • , if applicable, related disorders such as:
  • developmental and epileptic encephalopathy (G93.45)
  • developmental disorder of speech and language (F80.-)
  • developmental disorders of scholastic skills (F81.-)
  • epilepsy, by specific type (G40.-)
  • intellectual disabilities (F70-F79)
  • other neurodevelopmental disorder (F88)
  • pervasive developmental disorders (F84.-)
Code Also
  • , if applicable, any associated manifestations, such as:
  • other obesity (E66.8-)
  • polyphagia (R63.2)

Child Codes (More Specific Codes for Z15):

Z15.0 - Genetic susceptibility to malignant neoplasm Z15.01 - Genetic susceptibility to malignant neoplasm of breast Z15.02 - Genetic susceptibility to malignant neoplasm of ovary Z15.03 - Genetic susceptibility to malignant neoplasm of prostate Z15.04 - Genetic susceptibility to malignant neoplasm of endometrium Z15.09 - Genetic susceptibility to other malignant neoplasm Z15.1 - Genetic susceptibility to epilepsy and neurodevelopmental disorders Z15.2 - Genetic susceptibility to obesity Z15.8 - Genetic susceptibility to other disease Z15.81 - Genetic susceptibility to multiple endocrine neoplasia [MEN] Z15.89 - Genetic susceptibility to other disease

About ICD-10-CM Code Z15 (Genetic susceptibility to disease)

ICD-10-CM code Z15 is a billable or specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes. The 2025 edition of ICD-10-CM Z15 became effective on October 1, 2024.

This page provides detailed information about Z15 - Genetic susceptibility to disease. It includes common terminology, coding guidelines such as "Includes," "Excludes1," and "Excludes2" notes, and information on required 7th characters. Utilizing this information correctly is essential for accurate medical coding and claims submission for conditions like Genetic susceptibility to disease.