ICD-10-CM Z16: Resistance to antimicrobial drugs

ICD-10-CM Diagnosis Code (2025)

Official Description for Z16

Resistance to antimicrobial drugs

Coding Notes & Guidelines for Z16

Excludes1: Not Coded Here
  • Methicillin resistant Staphylococcus aureus infection (A49.02)
  • Methicillin resistant Staphylococcus aureus pneumonia (J15.212)
  • Sepsis due to Methicillin resistant Staphylococcus aureus (A41.02)
Excludes1: Not Coded Here

resistance to antibiotics (Z16.1-, Z16.2-)

Excludes1: Not Coded Here

Resistance to multiple antibiotics only (Z16.24)

Excludes2: Not Included Here

Methicillin resistant Staphylococcus aureus infection in diseases classified elsewhere (B95.62)

Code First

the infection

Inclusion Terms
  • Resistance to amoxicillin
  • Resistance to ampicillin
Inclusion Terms

Resistance to cephalosporins

Inclusion Terms

Resistance to antibiotics NOS

Inclusion Terms
  • Resistance to aminoglycosides
  • Resistance to macrolides
  • Resistance to sulfonamides
  • Resistance to tetracyclines
Inclusion Terms

Drug resistance NOS

Inclusion Terms

Resistance to quinine and related compounds

Inclusion Terms

Resistance to tuberculostatics

Inclusion Terms

Resistance to antimycobacterial drug NOS

Child Codes (More Specific Codes for Z16):

Z16.1 - Resistance to beta lactam antibiotics Z16.10 - Resistance to unspecified beta lactam antibiotics Z16.11 - Resistance to penicillins Z16.12 - Extended spectrum beta lactamase (ESBL) resistance Z16.13 - Resistance to carbapenem Z16.19 - Resistance to other specified beta lactam antibiotics Z16.2 - Resistance to other antibiotics Z16.20 - Resistance to unspecified antibiotic Z16.21 - Resistance to vancomycin Z16.22 - Resistance to vancomycin related antibiotics Z16.23 - Resistance to quinolones and fluoroquinolones Z16.24 - Resistance to multiple antibiotics Z16.29 - Resistance to other single specified antibiotic Z16.3 - Resistance to other antimicrobial drugs Z16.30 - Resistance to unspecified antimicrobial drugs Z16.31 - Resistance to antiparasitic drug(s) Z16.32 - Resistance to antifungal drug(s) Z16.33 - Resistance to antiviral drug(s) Z16.34 - Resistance to antimycobacterial drug(s) Z16.341 - Resistance to single antimycobacterial drug Z16.342 - Resistance to multiple antimycobacterial drugs Z16.35 - Resistance to multiple antimicrobial drugs Z16.39 - Resistance to other specified antimicrobial drug

About ICD-10-CM Code Z16 (Resistance to antimicrobial drugs)

ICD-10-CM code Z16 is a billable or specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes. The 2025 edition of ICD-10-CM Z16 became effective on October 1, 2024.

This page provides detailed information about Z16 - Resistance to antimicrobial drugs. It includes common terminology, coding guidelines such as "Includes," "Excludes1," and "Excludes2" notes, and information on required 7th characters. Utilizing this information correctly is essential for accurate medical coding and claims submission for conditions like Resistance to antimicrobial drugs.